Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
Identifieur interne : 001321 ( Main/Exploration ); précédent : 001320; suivant : 001322Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
Auteurs : A. Padovani [Italie] ; B. Borroni [Italie] ; S M Brambati [Italie] ; C. Agosti [Italie] ; M. Broli [Italie] ; R. Alonso [Italie] ; P. Scifo [Italie] ; G. Bellelli [Italie] ; A. Alberici [Italie] ; R. Gasparotti [Italie] ; D. Perani [Italie]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2006-04.
English descriptors
- KwdEn :
- BADL, basic activities of daily living, CDR, clinical dementia rating scale, CSF, cerebrospinal fluid, DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, fourth edition, DTI, diffusion tensor imaging, FA, fractional anisotropy, FBI, frontal behavioural inventory, FDR, false discovery rate, FWHM, full width at half maximum, GM, grey matter, IADL, instrumental activities of daily living, MMSE, mini-mental state examination, MNI, Montreal Neurological Institute, NPI, neuropsychiatric inventory, PSP, progressive supranuclear palsy, UPDRS, unified Parkinson disease rating scale, VBM, voxel based morphometry, WM, white matter, diffusion tensor imaging, magnetic resonance imaging, progressive supranuclear palsy, voxel based morphometry.
Abstract
Background: A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy (PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available. Objective: To evaluate grey and white matter changes in mild PSP patients by voxel based morphometry (VBM) and diffusion tensor imaging (DTI), respectively. Methods: 14 mild PSP patients and 14 healthy controls entered the study and underwent a clinical and neuropsychological evaluation according with a standardised assessment. Each subject had a structural magnetic resonance imaging (MRI) study. Processing analysis of MRI data was carried out according to optimised VBM and fractional anisotropy was determined. Results: Compared with the controls, in PSP patients VBM analysis showed a significant clusters of reduced grey matter in premotor cortex, frontal operculum, anterior insula, hippocampus, and parahippocampal gyrus, bilaterally. With regard to subcortical brain regions, the pulvinar, dorsomedial and anterior nuclei of the thalamus, and superior and inferior culliculum were affected bilaterally. A bilateral decrease in fractional anisotropy in superior longitudinal fasciculus, anterior part of corpus callosum, arcuate fascicolus, posterior thalamic radiations, and internal capsule, probably involving the cortico-bulbar tracts, was present in PSP patients. Conclusions: These data provide evidence for both grey and white matter degeneration in PSP from the early disease stage. These structural changes suggest that atrophy of cortical and subcortical structures and neurodegeneration of specific fibre tracts contribute to neurological deficits in PSP.
Url:
DOI: 10.1136/jnnp.2005.075713
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy</title><author><name sortKey="Padovani, A" sort="Padovani, A" uniqKey="Padovani A" first="A" last="Padovani">A. Padovani</name></author><author><name sortKey="Borroni, B" sort="Borroni, B" uniqKey="Borroni B" first="B" last="Borroni">B. Borroni</name></author><author><name sortKey="Brambati, S M" sort="Brambati, S M" uniqKey="Brambati S" first="S M" last="Brambati">S M Brambati</name></author><author><name sortKey="Agosti, C" sort="Agosti, C" uniqKey="Agosti C" first="C" last="Agosti">C. Agosti</name></author><author><name sortKey="Broli, M" sort="Broli, M" uniqKey="Broli M" first="M" last="Broli">M. Broli</name></author><author><name sortKey="Alonso, R" sort="Alonso, R" uniqKey="Alonso R" first="R" last="Alonso">R. Alonso</name></author><author><name sortKey="Scifo, P" sort="Scifo, P" uniqKey="Scifo P" first="P" last="Scifo">P. Scifo</name></author><author><name sortKey="Bellelli, G" sort="Bellelli, G" uniqKey="Bellelli G" first="G" last="Bellelli">G. Bellelli</name></author><author><name sortKey="Alberici, A" sort="Alberici, A" uniqKey="Alberici A" first="A" last="Alberici">A. Alberici</name></author><author><name sortKey="Gasparotti, R" sort="Gasparotti, R" uniqKey="Gasparotti R" first="R" last="Gasparotti">R. Gasparotti</name></author><author><name sortKey="Perani, D" sort="Perani, D" uniqKey="Perani D" first="D" last="Perani">D. Perani</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:36B1386BACEEF2C0B9D6AAA675EE610143FD4880</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1136/jnnp.2005.075713</idno><idno type="url">https://api.istex.fr/document/36B1386BACEEF2C0B9D6AAA675EE610143FD4880/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001646</idno><idno type="wicri:Area/Main/Curation">001412</idno><idno type="wicri:Area/Main/Exploration">001321</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy</title><author><name sortKey="Padovani, A" sort="Padovani, A" uniqKey="Padovani A" first="A" last="Padovani">A. Padovani</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Neurology, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Borroni, B" sort="Borroni, B" uniqKey="Borroni B" first="B" last="Borroni">B. Borroni</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Neurology, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Brambati, S M" sort="Brambati, S M" uniqKey="Brambati S" first="S M" last="Brambati">S M Brambati</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>“Vita-Salute”, San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Agosti, C" sort="Agosti, C" uniqKey="Agosti C" first="C" last="Agosti">C. Agosti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Neurology, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Broli, M" sort="Broli, M" uniqKey="Broli M" first="M" last="Broli">M. Broli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Neurology, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Alonso, R" sort="Alonso, R" uniqKey="Alonso R" first="R" last="Alonso">R. Alonso</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Scifo, P" sort="Scifo, P" uniqKey="Scifo P" first="P" last="Scifo">P. Scifo</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bellelli, G" sort="Bellelli, G" uniqKey="Bellelli G" first="G" last="Bellelli">G. Bellelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>“Ancelle della Carità” Hospital, Cremona</wicri:regionArea><wicri:noRegion>Cremona</wicri:noRegion></affiliation></author><author><name sortKey="Alberici, A" sort="Alberici, A" uniqKey="Alberici A" first="A" last="Alberici">A. Alberici</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS, Memory Clinic, Alzheimer Centre, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Gasparotti, R" sort="Gasparotti, R" uniqKey="Gasparotti R" first="R" last="Gasparotti">R. Gasparotti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroradiology, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Perani, D" sort="Perani, D" uniqKey="Perani D" first="D" last="Perani">D. Perani</name><affiliation wicri:level="3"><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Vita-Salute San Raffaele University, IRCCS San Raffaele and INB-CNR</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2006-04">2006-04</date><biblScope unit="volume">77</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="457">457</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">36B1386BACEEF2C0B9D6AAA675EE610143FD4880</idno><idno type="DOI">10.1136/jnnp.2005.075713</idno><idno type="href">jnnp-77-457.pdf</idno><idno type="PMID">16306152</idno><idno type="local">0770457</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BADL, basic activities of daily living</term><term>CDR, clinical dementia rating scale</term><term>CSF, cerebrospinal fluid</term><term>DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, fourth edition</term><term>DTI, diffusion tensor imaging</term><term>FA, fractional anisotropy</term><term>FBI, frontal behavioural inventory</term><term>FDR, false discovery rate</term><term>FWHM, full width at half maximum</term><term>GM, grey matter</term><term>IADL, instrumental activities of daily living</term><term>MMSE, mini-mental state examination</term><term>MNI, Montreal Neurological Institute</term><term>NPI, neuropsychiatric inventory</term><term>PSP, progressive supranuclear palsy</term><term>UPDRS, unified Parkinson disease rating scale</term><term>VBM, voxel based morphometry</term><term>WM, white matter</term><term>diffusion tensor imaging</term><term>magnetic resonance imaging</term><term>progressive supranuclear palsy</term><term>voxel based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy (PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available. Objective: To evaluate grey and white matter changes in mild PSP patients by voxel based morphometry (VBM) and diffusion tensor imaging (DTI), respectively. Methods: 14 mild PSP patients and 14 healthy controls entered the study and underwent a clinical and neuropsychological evaluation according with a standardised assessment. Each subject had a structural magnetic resonance imaging (MRI) study. Processing analysis of MRI data was carried out according to optimised VBM and fractional anisotropy was determined. Results: Compared with the controls, in PSP patients VBM analysis showed a significant clusters of reduced grey matter in premotor cortex, frontal operculum, anterior insula, hippocampus, and parahippocampal gyrus, bilaterally. With regard to subcortical brain regions, the pulvinar, dorsomedial and anterior nuclei of the thalamus, and superior and inferior culliculum were affected bilaterally. A bilateral decrease in fractional anisotropy in superior longitudinal fasciculus, anterior part of corpus callosum, arcuate fascicolus, posterior thalamic radiations, and internal capsule, probably involving the cortico-bulbar tracts, was present in PSP patients. Conclusions: These data provide evidence for both grey and white matter degeneration in PSP from the early disease stage. These structural changes suggest that atrophy of cortical and subcortical structures and neurodegeneration of specific fibre tracts contribute to neurological deficits in PSP.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Padovani, A" sort="Padovani, A" uniqKey="Padovani A" first="A" last="Padovani">A. Padovani</name></noRegion><name sortKey="Agosti, C" sort="Agosti, C" uniqKey="Agosti C" first="C" last="Agosti">C. Agosti</name><name sortKey="Alberici, A" sort="Alberici, A" uniqKey="Alberici A" first="A" last="Alberici">A. Alberici</name><name sortKey="Alonso, R" sort="Alonso, R" uniqKey="Alonso R" first="R" last="Alonso">R. Alonso</name><name sortKey="Bellelli, G" sort="Bellelli, G" uniqKey="Bellelli G" first="G" last="Bellelli">G. Bellelli</name><name sortKey="Borroni, B" sort="Borroni, B" uniqKey="Borroni B" first="B" last="Borroni">B. Borroni</name><name sortKey="Brambati, S M" sort="Brambati, S M" uniqKey="Brambati S" first="S M" last="Brambati">S M Brambati</name><name sortKey="Broli, M" sort="Broli, M" uniqKey="Broli M" first="M" last="Broli">M. Broli</name><name sortKey="Gasparotti, R" sort="Gasparotti, R" uniqKey="Gasparotti R" first="R" last="Gasparotti">R. Gasparotti</name><name sortKey="Perani, D" sort="Perani, D" uniqKey="Perani D" first="D" last="Perani">D. Perani</name><name sortKey="Scifo, P" sort="Scifo, P" uniqKey="Scifo P" first="P" last="Scifo">P. Scifo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001321 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001321 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:36B1386BACEEF2C0B9D6AAA675EE610143FD4880
|texte= Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
}}
| This area was generated with Dilib version V0.6.23. |  |